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Glucosylceramide synthase-IN-2
目录号:SY-128930
Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、具有血脑屏障通透性的、口服具有活力的 glucosylceramide synthase (GCS) 抑制剂,作用于人 GCS (IC50: 15 nM) 和小鼠 GCS (IC50: 190 nM)。Glucosylceramide synthase-IN-2 能够非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 能够用于研究戈谢病。
¥2346.00
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FTI 276
目录号:SY-128931
FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human).
¥6313.00
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D,L-erythro-PDMP hydrochloride
目录号:SY-128932
D,L-erythro-PDMP hydrochloride 是 PDMP 的赤型异构体。D,L-erythro-PDMP 诱导体外兔皮肤成纤维细胞的生长抑制。PDMP 是一种 UDP 葡萄糖神经酰胺葡萄糖基转移酶抑制剂。
¥1150.00
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Glucosylceramide synthase-IN-1
目录号:SY-128933
Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、口服具有活力的、具有血脑屏障通透性的 glucosylceramide synthase (GCS) 抑制剂,作用于人 GCS (IC50: 31 nM) 和小鼠 GCS (IC50: 51 nM)。Glucosylceramide synthase-IN-1 能够用于研究戈谢病。
¥1978.00
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D,L-erythro-PDMP
目录号:SY-128934
D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.
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Andrastin A
目录号:SY-128935
Andrastin A 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125574,CAS号为 174232-42-9。
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D-threo-PPMP hydrochloride
目录号:SY-128936
D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)
¥4025.00
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Zaragozic acid A trisodium
目录号:SY-128937
Zaragozic acid A trisodium 是真菌的代谢产物,具有作为角鲨烯合成酶可逆竞争性抑制剂的功能。
¥9120.00
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Miglustat-D9 hydrochloride
目录号:SY-128938
Miglustat-D9 hydrochloride为Miglustat Hydrochloride (TQ0155)的氘代物,属于葡萄糖神经酰胺合成酶抑制剂,主要用于治疗I型戈谢病。
¥3468.00
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