Frutinone A 是一种具有色原香豆素结构支架的CYP1A2抑制剂，其显示出抗菌和抗氧化等多种生物活性。

Perilla ketone 是一种天然呋喃类单萜化合物，主要存在于唇形科植物紫苏（Perilla frutescens）中。Perilla ketone 具有显著的肺毒性，Perilla ketone 可以被肺中的肺 P450 细胞色素酶激活，导致严重的肺损伤和弥漫性肺水肿的发展。

orally active ghrelin receptor (GHS-R1a) agonist

PROTACCYP1B1 degrader-1 (Compound 6C) 是一种 α-萘黄酮嵌合衍生物，能够通过靶向 CYP1B1降解消除细胞色素 P450 (CYP)1B1 介导的耐药性，对 CYP1B1 和 CYP1A2 的 IC50分别为 95.1 和 9838.6 nM。PROTACCYP1B1 Degrader-1 可用于研究 CYP1B1过表达的前列腺癌。

Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes).

Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer.

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM.

CYP2E1-IN-1 (Compound 10) 是一种口服有效的细胞色素 P450 2E1 (CYP2E1) 抑制剂，具有Kd为 7.02 μM，IC50为 1.64 μM，Ki为 0.897 μM的特性。该化合物通过激活Nrf2/HO-1信号通路来降低ROS的产生，从而缓解胰腺损伤。CYP2E1-IN-1 具备显著的抗炎和抗氧化活性，能够有效减轻严重急性胰腺炎 (SAP) 的炎症及氧化应激，并可用于SAP及其他炎症相关疾病的研究。

Peucedanol acts as a non-competitive inhibitor of CYP3A4 with a K i value of 4.07 μM, while serving as a competitive inhibitor for CYP1A2 and CYP2D6 with K i values of 3.39 μM and 6.77 μM, respectively [1].