Acetylcholine-D16 bromide是Acetylcholine bromide (T20344)中氘置换的一种形式。

(S)-Amlodipine-D4是(S)-Amlodipine (T1545)的氘代化合物。 (S)-Amlodipine的CAS号为103129-82-4。Levamlodipine是一种二氢吡啶钙通道阻滞剂，具有舒张血管的作用，可用于高血压和心绞痛的研究。

L-Ascorbic Acid-13C6是L-Ascorbic Acid (T0928)的 13C 的标记化合物。L-Ascorbic Acid的CAS号为50-81-7。L-Ascorbic acid是一种电子供体，是一种内源性抗氧化剂。它选择性抑制 Cav3.2 通道，IC50为 6.5 μM。它还是一种胶原沉积促进剂和弹性生成抑制剂，可对抗细菌感染、解毒反应和胶原蛋白的形成。

Gabapentin-D4是Gabapentin (T0702)的氘代化合物。Gabapentin的CAS号为60142-96-3。Gabapentin是GABA类似物，是一种抗癫痫药，可用于缓解神经性疼痛。

Isotachysterol 3 是一种活性维生素 D 结构类似物的开环甾体化合物，也是制备维生素 D₃ 过程中的一种杂质。Isotachysterol 3 在无肾大鼠模型中能够显著刺激肠道钙的转运和骨钙动员。Isotachysterol 3 可用于不依赖于肾脏 1α-羟化的维生素 D 代谢研究。

Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. It also accumulates in the urine, kidney, and plasma of patients with Fabry disease. Lyso-globotriaosylceramide levels decrease in response to administration of the α-galactosidase inhibitor 1-deoxygalactonojirimycin in a transgenic mouse model of Fabry disease. Decreases in plasma and urine concentrations of lyso-globotriaosylceramide have been used as a biomarker for efficacy of enzyme replacement th

Argireline acetate 显着抑制神经肌肉接头处 Ca2+ 依赖性神经递质（乙酰胆碱）的释放。 Argireline acetate 具有抗皱和抗衰老活性。

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 μM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 μM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.

17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.3,4 1.Schwarz, D., Kisselev, P., Ericksen, S.S., et al.Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: Highly steroselective formation of 17(R), 18(S)-epoxyeicosatetraenoic acidBiochem. Pharmacol.67(8)1445-1457(2004) 2.Lauterbach, B., Barbosa-Sicard, E., Wang, M.H., et al.Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activatorsHypertension39(2 Pt. 2)609-613(2002) 3.Falck, J.R., Wallukat, G., Puli, N., et al.