Thyroid hormone receptor beta agonist-1 (compound 3) 作为thyroid beta 的有效激动剂。

VK-0214 是一种甲状腺 β 受体 (TRβ) 激动剂，能够通过激活 ABCD2 表达并减少极长链脂肪酸 (VLCFA) 的积累，有效改善 X 连锁肾上腺脑白质营养不良 (X-ALD)。

ABX-002 (MA-JD21) 是一种 TR-β 选择性中枢神经系统渗透型 TR-β 激动剂前药，可用于重度抑郁症 (MDD) 的研究。

Hypercalcemia Malignancy Factor (1-34), human 是多肽分子，其序列是 AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTA。

Sob-AM2为一种针对大脑中表达的脂肪酸酰胺水解酶（FAAH）的有效底物，其Km值为1.3 μM。该化合物能在最小的外周全身剂量下向中枢神经系统输送较高浓度的Sobetirome，从而激活中枢的甲状腺激素受体β（TRβ）。

Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.

3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 μM, respectively, in cell-free assays).2N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50= 1.07 μM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 μM, respectively).3 1.Van Beeren, H.C., Jong, W.M.C., Kaptein, E.,

Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.