urotensin-II (UT) receptor antagonist

rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3 1.Hung, W.-C., Peng, G.-J., Tsai, W.-J., et al.Identification of 3-MCPD esters to verify the adulteration of extra virgin olive oilFood Addit. Contam. Part B Surveill.10(3)233-239(2017) 2.MacMahon, S., Begley, T.H., and Diachenko, G.W.Occurrence of 3-MCPD and glycidyl esters in edible oils in the United StatesFood Addit. Contam. Part A. Chem. Anal. Control Expo. Risk Assess.30(12)2081-2092(2013) 3.Liu, M., Gao, B.-Y., Qin, F., et al.Acute oral toxicity of 3-MCPD mono- and di-palmitic esters in Swiss mice and their cytotoxici

(S)-GLPG0974 是 GLPG0974 的异构体，用作实验的对照化合物。GLPG0974 作为游离脂肪酸受体-2 [free fatty acid receptor-2 (FFA2/GPR43)] 的拮抗剂，其 IC50 为 9 nM。

(R)-Fasiglifam 是 Fasiglifam 的异构体，用作实验对照。Fasiglifam (TAK-875) 是一种有效的、可口服的选择性 GPR40 激动剂，其 EC50 为 72 nM。

MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).

Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.

Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).

AMG 837 hemicalcium 是一种有效的、口服具有活力的 GPR40/FFA1部分激动剂。AMG 837 hemicalcium 能够抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合 (pIC50: 8.13)。AMG 837 hemicalcium 能够提高啮齿动物的胰岛素分泌，减少葡萄糖水平。

[Orn8]-Urotensin II 是一种 Urotensin 受体配体和 Urotensin 受体的部分激动剂。