Lubabegron, also known as LY591281; LY488756 fumarate, is a veterinary drug used to reduce ammonia emissions from animals and their waste. Ammonia emissions are a concern in agricultural production because of detrimental effects on the environment, human health, and animal health. Lubabegron was approved by the U.S. Food and Drug Administration in 2018 for use in feedlot cattle. Lubabegron is a beta-adrenergic receptor agonist that has the effect of increasing the breakdown of fats and increasing energy expenditure in cells.

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.

non-steroidal androgen receptor (AR) antagonist

Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.

Androgen receptor degrader-1 (compound 18)作为高效的雄激素受体降解剂, 主要应用于癌症研究。

YXG-158（Compound 23-h）是具有口服活性的AR降解剂和CYP17A1抑制剂。该化合物的AR降解活性表现在其DC50值为1.28 μM，而对CYP17A1的抑制作用则体现在其IC50值为100 nM。YXG-158适用于研究恩杂鲁胺耐药性前列腺癌。

Galloylalbiflorin (6′-O-Galloylalbiflorin) 为芍药根部提取的雄性激素受体 (AR) 拮抗剂，具IC50值为53.3 μM，展现抗雄激素活性。

FSHR agonist 1是一种对卵泡刺激素(FSH)受体(FSHR)具有高亲和力并能引起变构的激动剂，具有pEC50值为7.72。它通过与TMD广泛相互作用直接激活FSHR。

Estrone-d4 是 Estrone 的氘代化合物。Estrone 的 CAS 号为 53-16-7。Aquacrine是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。