hCAIX-IN-18 (compound 30) 作为一种碳酸酐酶抑制剂，对不同亚型碳酸酐酶的Ki值表现出得相应抑制效果，具体为hCAI的Ki值为3.5 nM，hCAII的Ki值为9.4 nM，hCAIX的Ki值为43.0 nM，以及hCAXII的Ki值为8.2 nM。

Carbonic anhydrase 是一类含锌金属酶，能高效催化二氧化碳的可逆水合反应。Carbonic anhydrase 可用于癌症、青光眼、肥胖症和癫痫症的研究。

Carbonic Anhydrase Inhibitor2 (compound 7c) 是一种针对 Carbonic Anhydrase II 抑制剂，有效降低青光眼兔眼压。

LKY-047, a derivative of Decursin, is a highly effective and specific reversible competitive inhibitor of cytochrome P45022J2 (CYP2J2), with an IC 50 value of 1.7 μM. LKY-047 does not display inhibitory activity against other human P450 enzymes including CYPs 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A.

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM.