Gypenoside LI是一种具有抗癌活性的天然产物，能够产生ROS，下调procaspase-8和MMP-2/9，抑制Wnt/β-catenin，引起细胞周期阻滞和凋亡。

inhibitor of cancer stem cells

YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.

Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.

9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.9-Hydroxycanthin-6-one inhibits Wnt signaling through the activation of GSK3β independent of CK1α.

WAY 316606 hydrochloride是一种sFRP-1分泌蛋白抑制剂，兼作分泌性糖蛋白Wnt的拮抗剂。在FP结合检测中，其对sFRP-1的IC50为0.5 μM。