Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil .1It is also a potential impurity found in commercial preparations of sildenafil. 1.Nagaraju, V., Sreenath, D., Rao, J.T., et al.Separation and determination of synthetic impurities of sildenafil (Viagra) by reversed-phase high-performance liquid chromatographyAnal. Sci.19(7)1007-1011(2003)

Saterinone hydrochloride is an inhibitor of phosphodiesterase III (PDE III).

Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity.

Phyllodulcin 是绣球花 (Hydrangea macrophyllavar.thunbergii) 提取的一种具口服活性的甜味剂。作为非选择性的 phosphodiesterase 抑制剂，Phyllodulcin 能够抑制淋巴细胞的活化，从而展现出抗过敏的功能。此外，该化合物还通过调节瘦素水平、影响脂肪褐化相关基因及下丘脑 BDNF-TrkB 信号通路来抵抗肥胖。

PDE10-IN-5 是一种磷酸二酯酶 10 (PDE 10) 抑制剂，能够用于研究某些中枢神经系统疾病。

DSR-141562 is a new compound that can be taken orally and has a specific ability to inhibit phosphodiesterase 1 (PDE1) in the brain. This compound exhibits a preference for inhibiting human PDE1B, with an IC50 value of 43.9 nM. It also shows moderate inhibition of human PDE1A (IC50 = 97.6 nM) and PDE1C (IC50 = 431.8 nM). DSR-141562 is particularly useful in the study of positive symptoms, negative symptoms, and cognitive impairments associated with schizophrenia.