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DKI5
目录号:SY-127527
DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) 是一种 LOX-1 抑制剂,IC50 值为 22.5 μM。DKI5 可能具有抗炎和抗氧化活性,在体外生物测定中显示出抗脂质过氧化活性。
¥575.00
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Plathymenin
目录号:SY-127528
Plathymenin 是一种从 Spatholobus suberectus 中分离出来的天然产物。
¥1150.00
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3-Chloroiminodibenzyl
目录号:SY-127529
3-Chloroiminodibenzyl是一个片段分子,CAS号为32943-25-2,可作为分子拼接、扩展和修饰的重要骨架,为新型候选药物的设计与筛选提供结构基础与研究工具,常用于药物发现、药物合成等相关研究。
¥2070.00
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17(S)-HpDHA
目录号:SY-127530
17(S)-HpDHA为主要由15-Lipoxygenase(LOX)同工酶:h15-LOX-1和h15-LOX-2与二十二碳六烯酸(DHA)反应生成。该化合物通过变构负向调控环氧化物合成,且能够抑制血小板聚集,其EC50值约为1μM。
¥345.00
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Lobaric acid
目录号:SY-127531
Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM). In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).
¥575.00
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(±)15-HEDE
目录号:SY-127532
(±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid. There are no reports in the literature of biological activity associated with (±)15-HEDE.
¥1150.00
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