Ganodermanontriol

目录号：SY-110266

Ganodermanontriol 是从 GL 中提取得到的纯化三萜化合物，能够抑制结肠癌细胞 HCT-116 和 HT-29 的增殖，同时不显著影响细胞活性，并呈剂量依赖性抑制 β-catenin 转录活性及 cyclin D1 表达，减少 Cdk-4 与 PCNA，同时增加 HT-29 细胞中 E-cadherin 与 β-catenin 累积。在 HT-29 异种移植小鼠模型中，其可显著抑制肿瘤生长且无明显毒性，表明其在结直肠癌化疗研究中具有良好应用前景。

¥2204.00

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UU-T01

目录号：SY-110267

UU-T01 是 β-Catenin/T-cell factor 4 蛋白互作 (β-catenin/Tcf PPI) 的选择性抑制剂，Ki 值为 3.14 µM。UU-T01 与β-catenin 直接结合，KD 值为 0.531 µM。

¥1725.00

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16,16-Dimethyl prostaglandin E2

目录号：SY-110268

16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.

¥3036.00

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A3334

目录号：SY-110269

A3051, is a robust and orally active inhibitor of CXXC5-DVL with an IC 50 of 63.06 nM. Its applications include research into phenotypes associated with obesity, diabetes, and NASH that are induced by high fat diet (HFD) and methionine-choline deficient diet (MCD).

¥1828.00

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TWS-119

目录号：SY-110270

TWS-119是一种强效 GSK-3β 抑制剂，可激活 Wnt/β-catenin 信号通路。它能诱导神经元分化，增强 T 细胞抗肿瘤活性，并在缺血性卒中模型中保护血脑屏障。

¥920.00

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GNF-1331

目录号：SY-110271

GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers.

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