TAT-TCL1-Akt-in 是一款有效的Akt抑制剂。

substrate for Akt/PKB

IPL344 保护各种类型的细胞免受促凋亡压力影响，并激活Akt信号传导。IPL344 可用于 [肌萎缩侧索硬化症 (ALS)] 的研究。

Scalaradial 是一种抑制剂，针对蜂毒磷脂酶 A2 (PLA2) 和TRPM离子通道 (TRPM2) 的IC50分别为 0.07 和 0.21 μM。它通过抑制分泌性PLA2和Akt，调节ERK的磷酸化。Scalaradial 还可以抑制PMA诱导的小鼠腹膜巨噬细胞中Arachidonic acid的释放。

Itacnosertib hydrocholide为JAK2、ACVR1 (ALK2) 及ALK5的抑制剂。

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.