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Flavokawain 1i
目录号:SY-109620
Flavokawain 1i是chalcones的派生物,包括flavokawain A、flavokawain B和flavokawain C,具有抗癌和抗病毒活性。在30 µM浓度下,Flavokawain 1i能够抑制gefitinib抵抗性的H1975非小细胞肺癌(NSCLC)细胞的增殖率达到36%,同时降低热休克蛋白90(Hsp90)客体蛋白EGFR、c-Met、HER2、Akt和细胞周期依赖性激酶4(Cdk4)的蛋白水平,并提高Hsp70蛋白水平,这是Hsp90抑制的标志。肌肉内给药的Flavokawain 1i能够降低感染猪生殖与呼吸综合征病毒(PRRSV)猪只的病毒滴度。
¥1414.00
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Hsp90-IN-17 hydrochloride
目录号:SY-109621
Hsp90-IN-17 (Example 5) hydrochloride,一种针对增殖性疾病如癌症和神经退行性疾病研究的HSP90抑制剂。
¥782.00
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Retaspimycin
目录号:SY-109622
Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).
¥2565.00
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Palmitic acid-13C
目录号:SY-109623
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.3,4,5,6,7
¥471.00
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Palmitic acid-16,16,16-d3
目录号:SY-109624
Palmitic acid-16,16,16-d3 是 Palmitic acid 的氘代化合物。Palmitic acid 的 CAS 号为 57-10-3。Palmitic acid 是在动物、植物和微生物中发现的最常见的饱和脂肪酸,具有抗肿瘤活性。它可诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 和 CCAAT/增强子结合蛋白同源蛋白的表达。
¥897.00
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Hsp90-IN-37
目录号:SY-109625
Hsp90-IN-37 (Z-2) 是一种热休克蛋白90(Hsp90)抑制剂,对Hsp90酶活性抑制率达到69%,并具有抗肿瘤活性。
¥518.00
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