Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。

MG-2119 是单体 tau 和 α-syn aggregation 的有效抑制剂，能够用于研究神经疾病。

Semorinemab(RG6100)是一种人源化单克隆抗体，靶向Tau蛋白的N端结构域，Kd=3.8nM，可用于研究阿尔茨海默病的研究。Semorinemab能够结合所有六种人类tau同工型，减少Tau积累。

Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety for activity. Biochemistry. 41 9109 PMID:12119025 |Bennett et al (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle. 11 3045 PMID:22871740 |Bennett et al (2010) Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. Chem.Biol. 17 725 PMID:20659685

PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.

JG-23是一种4-氯修饰类似物，能促进t-tau降解，并在小鼠肝微粒体检测中显示出良好的代谢稳定性，具备较长的半衰期(T1/2值为36分钟)。