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GK187
目录号:SY-128408
GK187 是一种具有选择性和高效性的 Group VIA 钙非依赖性磷脂酶A2 (GVIA iPLA2) 抑制剂,可用于研究神经系统疾病。
¥2128.00
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Tipifarnib (S enantiomer)
目录号:SY-128892
Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体,它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂,IC50=0.6 nM。
¥1240.00
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N-(p-amylcinnamoyl) Anthranilic Acid
目录号:SY-128381
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶 A2(PLA2) 抑制剂,也是TRP channel 的阻滞剂。ACA 也可逆的抑制钙离子激活氯通道 (calcium-activated chloride channels) ,在心律失常方面具有研究的潜力。
¥256.00
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YM-53601 free base
目录号:SY-128919
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.
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Entacapone acid
目录号:SY-128901
Entacapone acid (AG 1290) 是一种选择性和可逆的儿茶酚-O-甲基转移酶 (COMT) 抑制剂。
¥129.00
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7β,27-dihydroxy Cholesterol
目录号:SY-128534
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human na ve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate and ionomycin .
¥5742.00
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