Clozic (ICI 55897) 作为一种小分子抗关节炎候选物，通过可逆地抑制滑膜细胞过度增殖发挥抗炎作用，可用于类风湿性关节炎及相关炎症疾病的机制研究。

Gisadenafil (UK-369003) 是一种特异性磷酸二酯酶 5 (PDE5) 抑制剂，IC50 为 3.6 nM，可防止 cGMP 降解。

Mopidamol (RA 233) 是一种磷酸二酯酶抑制剂，是 dipyridamole 衍生物，具有抗癌活性，可预防实验性糖尿病的视网膜血管缺陷。

4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterases. It is a more preferable substrate to 5'-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.

Enpp-1-IN-5 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。ENPP 1 显示出广泛的特异性，能够切割多种底物（包括核苷酸和核苷酸糖的磷酸二酯键、核苷酸和核苷酸糖的焦磷酸键）。 Enpp-1-IN-5 具有潜力进行癌症和传染病的研究。

Lodenafil carbonate, a prodrug dimer that delivers Lodenafil in vivo, is an orally active inhibitor of phosphodiesterase type 5 (PDE5), indicated for the treatment of erectile dysfunction (ED)[1][2].