Obscurolide A1 是一种可从链霉菌 viridochromogenes 的培养硝酸盐中分离出的丁内酯，对牛的钙/钙调节非依赖性和非依赖性磷酸二酯酶表现出较弱的抑制活性

D-mannoheptose is the main non-structural carbohydrate in avocado. D-mannoheptose is a specific inhibitor of D-glucose phosphorylation. D-mannoheptose can prevent the release of insulin and the utilization of carbohydrates in rats.

Nagilactone B is extracted from the root bark of Podocarpus nagi and it also is a liver X receptor (LXR) agonist.

Racecadotril-D5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril (T1176) is a prodrug form of the neprilysin (NEP)inhibitor thiorphan. In vivo,racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg,respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea. Formulations containing racecadotril have been used in the treatment of acute diarrhea.

22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as preven

ML-211 是基于氨基甲酸酯的酰基蛋白硫酯酶1 / 溶血磷脂酶1 (IC50=17 nM) 和LYPLA2(IC50=30 nM) 的双重抑制剂。它能够抑制丝氨酸水解酶ABHD11 (IC50=10 nM)，但在 20 个丝氨酸水解酶组合中，对 LYPLA 的选择性为 50 倍。