TZ9 是一种具有选择性和有效性的 Rad6 抑制剂，具有抗癌和而抗肿瘤活性。TZ9 对 Rad6B 诱导的组蛋白 H2A 泛素化有抑制作用。TZ9 诱导细胞周期停滞和细胞凋亡。

UC-764864 是一种选择性 UBE2N 抑制剂，阻断了 E1-UBE2N 硫酯转移，可抑制先天免疫信号传导并诱导 MDS/AML 细胞系和原代细胞的细胞毒性作用。此外，UC-764864 可降低 UBE2N 的泛素化状态，可用于研究白血病。

Skp2 Inhibitor C1 (SKPin C1)(SKPin C1)是Skp2介导p27降解的特异性抑制剂。

BC-1382 是E3泛素连接酶HECTD2抑制剂，能够特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。BC-1382具有抗炎活性。

Auxinole 是TIR1/AFB 受体植物激素拮抗剂。它可与 TIR1 结合，阻断 TIR1-IAA-Aux/IAA 复合物的形成，抑制 auxin 应答基因的表达。

Subasumstat (TAK-981) 是SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤特性。

8RK59 is a PARK7 inhibitor.

XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs

LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Moreover, LXE408 shows limited ability to traverse the blood-brain barrier. Hence, LXE408 holds promise for advancing research in the field of visceral leishmaniasis (VL).