SHP2 inhibitor LY6 (LY6) 是一种有效的、选择性的 SHP2 抑制剂 (IC50: 9.8 μM)。SHP2 inhibitor LY6 能够阻碍 SHP2 介导的细胞信号传导和增殖。

DSHN is a small heterodimer partner (SHP) activator. DSHN transcriptionally activates SHP mRNA, and stabilizes the SHP protein by preventing its ubiquitination and degradation.

Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.

Microcystin-LR (Cyanoginosin-LR) 是一种蛋白磷酸酶 1 型和 2A 型的有效抑制剂，其 IC50值分别为 1.7 nM，0.04 nM。

Microcystin-RR (Cyanoviridin RR)，一种有效的口服活性蛋白磷酸酶抑制剂，能诱导细胞凋亡和小鼠肝脏内质网应激。

SHP2-IN-6 hydrochloride is a highly potent inhibitor of SHP2 with an IC50 of 25.8 nM.

A12B4C3 is a selective inhibitor of hPNKP phosphatase.