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Tauro-α-muricholic Acid (sodium salt)
目录号:SY-126114
Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but has also been found in small amounts in human serum.
¥3610.00
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5-Hydroxyferulic acid
目录号:SY-126115
5-Hydroxyferulic acid is an important hydroxycinnamic acid compound and a metabolite in the phenylpropanoid pathway. It acts as a precursor for the biosynthesis of sinapic acid and functions as a non-esterified substrate for COMT.
¥3610.00
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3,3-Dimethyl-1-butanol
目录号:SY-126116
3,3-Dimethyl-1-butanol (DMB)是一种口服有效的三甲胺(TMA)和三甲基胺-N-氧化物(TMAO)抑制剂,能够抑制p65NF-κB和TGF-β1/Smad3信号通路,展示了在心血管疾病(CVD)中的潜在应用。
¥165.00
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1a,1b-dihomo Prostaglandin F2α
目录号:SY-126117
1a,1b-Dihomo Prostaglandin F2α (1a,1b-dihomo PGF2α), a hypothetical product of adrenic acid in the COX pathway, is predominantly synthesized in the renal medulla, reflecting the selective distribution of adrenic acid in this region.
¥5016.00
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3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid
目录号:SY-126118
Sialic acids, commonly present as terminal carbohydrates on glycoconjugates, are essential for a variety of cellular functions including cell adhesion and signal recognition, as well as the formation and progression of tumors. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is a deaminated sialic acid that was first identified at the nonreducing ends of oligosialyl chains in rainbow trout egg glycoprotein.[1] It is thought to be a precursor for the biosynthesis of other members of the sialic acid family.[2] 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid can be used to analyze nonulosonic acid residues in polysialoglycoproteins.[1]
¥1282.00
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Dopamine 3-O-sulfate
目录号:SY-126119
Dopamine 3-O-sulfate是Dopamine的磺化代谢物,主要存在于血浆中。Dopamine 3-O-sulfate也是帕金森患者L-dopa的代谢终产物。
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17-Epiestriol
目录号:SY-126120
17-Epiestriol 是雌酮的内源性代谢产物,其形成过程经由 16α-羟基雌酮中间体,随后在 C-17 位酮基发生还原。17-Epiestriol 可与雌激素受体 α 和雌激素受体 β 结合,其相对结合亲和力分别为 29 和 80(以 17β-estradiol 为参照),支持其在雌激素信号转导、代谢过程及受体选择性研究中的相关性。
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Osteocalcin (1-49) (human) (trifluoroacetate salt)
目录号:SY-126121
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women. In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics. It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.
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Urate oxidase
目录号:SY-126122
Urate oxidase (Uox) 尿酸氧化酶,即尿酸酶,常用于生化研究。Urate oxidase 是一种过氧化物酶,在大多数哺乳动物中催化尿酸氧化为尿囊素。
¥627.00
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