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OPC 8490 free base
目录号:SY-123274
OPC 8490 free base 是新型正性肌力血管扩张剂,也是一种强心剂,以剂量依赖性和可逆的方式增加 Ca 电流,可用于研究心血管疾病。
¥1495.00
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L-Phenylalanine-15N
目录号:SY-123178
L-Phenylalanine-15N是15N 标记的 L-Phenylalanine。L-Phenylalanine是从大肠杆菌中分离出来的一种必需氨基酸。L-Phenylalanine (T3377)广泛用于食品香精和药物的生产。
¥167.00
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Araloside X
目录号:SY-123250
Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi
¥3420.00
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NS-638
目录号:SY-123224
NS-638 是一种 Ca2+ 通道阻滞剂,可阻断 K+ 刺激的细胞内 Ca2+ 升高,IC50值为3.4 μM。
¥385.00
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TPC2-A1-P
目录号:SY-123182
TPC2-A1-P 是一种具有膜渗透性的双孔通道 2 (TPC2) 激动剂,可差异激活双孔通道 2 (TPC2) 并模拟 TPC2 与 NAADP 和 PIP(2) 的激活。TPC2-A1-P 可用于研究神经退行性溶酶体贮积症。
¥1056.00
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17R(18S)-EpETE
目录号:SY-123390
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.3,4 1.Schwarz, D., Kisselev, P., Ericksen, S.S., et al.Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: Highly steroselective formation of 17(R), 18(S)-epoxyeicosatetraenoic acidBiochem. Pharmacol.67(8)1445-1457(2004) 2.Lauterbach, B., Barbosa-Sicard, E., Wang, M.H., et al.Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activatorsHypertension39(2 Pt. 2)609-613(2002) 3.Falck, J.R., Wallukat, G., Puli, N., et al.
¥1725.00
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JTV-519 fumarate
目录号:SY-123296
JTV-519 fumarate (K201 fumarate) 是 一种 SERCA 阻断剂和兰尼碱受体的部分激动剂,具有抗心律失常和心脏保护作用,可改善肌浆网钙渗漏,可用于研究焦虑症。
询价
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TMB 8 (hydrochloride)
目录号:SY-123388
TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 μM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 μM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.
¥1078.00
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Pyr6
目录号:SY-123238
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。
¥275.00
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