(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease.

GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).

Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM.

P2Y2R/GPR17 antagonist 1 (Compound 14m) 是一种双重的 P2Y2R (IC50: 3.17 μM) 和 GPR17 (IC50: 1.67 μM) 拮抗剂。P2Y2R/GPR17 antagonist 1 在人肝微粒体中表现出极好的代谢稳定性。

MCHR1 antagonist 2 是有效的黑色素聚集激素受体 1 拮抗剂，IC50为 65 nM。它也抑制hERG，在IMR-32 细胞中的IC50为 4.0 nM。

YE 120 是一种高效的 GPR35 激动剂（EC50：32.5 nM），具有潜在的抗炎抗癌活性，可用研究和G蛋白偶联受体相关的疾病。

CID1231538 是一种苯并噻唑类似物，是 GPR35拮抗剂。其中 GPR35 是一种 G 蛋白偶联受体 (GPCR)。

AZ12216052 是一种 GRP8 拮抗剂，具有抗焦虑和抗炎活性，可用于研究肥胖和代谢紊乱。

LP-471756 是 GPR139 的特异性拮抗剂，可抑制 LP-360924 刺激的 cAMP 产生 (IC50 = 640 nM)。