Mirogabalin besylate is a potent and orally active ligand that selectively targets the α2δ subunit of voltage-gated calcium channels. It displays high affinity (K d ) values, namely 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM, for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.

Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is a second messenger that promotes the release of calcium ions from the endoplasmic reticulum.

Selective blocker of CaV2.1 P/Q-type calcium channels.

IP3RPEP6 是一种 IP3R 的竞争性抑制剂，对 IP3R1、IP3R2 和 IP3R3 的 IC50 分别为 9.0 μM、3.9 μM 和 4.3 μM。IP3RPEP6 不影响雷诺丁受体和 Cx43 半通道，并能调节细胞内钙信号。

ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55 nM , respectively).