Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, inhibiting autophagic flux and synergistically enhancing the anticancer activity of chemotherapeutic agents against HeLa cells. Pulsatilla saponin D has strong haemolytic activity.

Chicanine是一种天然的木酚素，能够抑制巨噬细胞中LPS诱导的p38 MAPK，ERK1/2和IκB-α的磷酸化水平，具有抗炎活性。

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases

Lidocaine-D10 hydrochloride是Lidocaine Hydrochloride (T1144)的氘代化合物。Lidocaine Hydrochloride的CAS号为73-78-9。Lidocaine hydrochloride 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。

ERK1/2 inhibitor 9 (Probe 1)为共价ERK1/2抑制剂，具备亚微摩尔级别的细胞活性(A375 GI50=0.47 μM)，能够下调磷酸化ERK1/2。通过与反式环辛烯(TCO)标记的Tz-Thalidomide相结合，ERK1/2 inhibitor 9可形成ERK-CLIPTAC，进而触发ERK1/2的降解。

Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer[1]. ERK-IN-1 (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1]. [1]. CAPONIGRO, et al. THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR. WO2018051306A1.