Neoantimycin is an antibiotic originally isolated from S. orinoci that has slight antifungal activity. It is structurally similar to antimycin despite being produced by an unrelated species of Streptomyces. The biosynthetic pathway of neoantimycin has been determined and active analogs discovered.

SEW84 是 Aha1 刺激的 Hsp90(ASH) ATP 酶活性的抑制剂。SEW84 抑制 Aha1 刺激的 Hsp90(ASH) 活性，IC50值为 0.3 μM。SEW84 可用于蛋白质沉积疾病的研究。

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.

SMTIN-T140（化合物6a）是一种TRAP1（肿瘤坏死因子受体相关蛋白1）的高效抑制剂，IC50值为1.646 μM。该化合物表现出显著的抗癌活性，可引起线粒体功能障碍，增加线粒体ROS产生以及激活AMPK。在PC3前列腺癌细胞异种移植的小鼠模型中，SMTIN-T140有效抑制了肿瘤生长，并显示出良好的体内安全性。

YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.

PDK-IN-1（compound 7o）是一种针对丙酮酸脱氢酶激酶（PDK）的抑制剂，其对PDK1和HSP90的IC50值分别为0.03和0.1μM。通过靶向PDH/PDK轴，PDK-IN-1能有效降低肿瘤质量。