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ML202
目录号:SY-128164
ML202作为一种变构激活剂,针对人丙酮酸激酶M2 (hPK-M2)展现出高度特异性,能够影响磷酸烯醇丙酮酸(PEP)结合的协同性,而对二磷酸腺苷(ADP)的结合几乎无影响。
¥868.00
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Benserazide
目录号:SY-128156
Benserazide is an inhibitor of dopa decarboxylase. It is often given with levodopa in the treatment of Parkinson's to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system an
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Benserazide hydrochloride
目录号:SY-128148
Benserazide hydrochloride (Ro 4-4602) 是一种芳香族 L-氨基酸脱羧酶(AADC)的抑制剂,常用于帕金森病。
¥5175.00
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Acetyl hexapeptide 38
目录号:SY-128140
Acetyl hexapeptide 38 是一种乙酰化六肽,能显着刺激脂肪合成部位的使用,增加胸部或脸颊的体积,塑造完美身材
¥2852.00
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PF-04449613
目录号:SY-128132
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-04449613 (10 mg/kg) increases the rate of dendritic spine formation and elimination in mouse primary motor cortex pyramidal neuronsin vivo.2It increases the average running speed of mice in an accelerating rotarod task, indicating improved motor learning, at the same dose. 1.Claffey, M.M., Helal, C.J., Verhoest, P.R., et al.Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitorsJ. Med. Chem.55(21)9055-90
¥1955.00
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PDE7 inhibitor S14
目录号:SY-128124
PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway.
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