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Cleomiscosin C
目录号:SY-127179
Cleomiscosin C has antioxidant activity, it protects against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl ( IC50s of 23.6 and 3.9 microM, respectively), suggests that it could be beneficial in preventing LDL oxidation in atheroscl
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Thioquinapiperifil dihydrochloride
目录号:SY-127944
Thioquinapiperifil dihydrochloride 是一种磷酸二酯酶(PDE-5)抑制剂(IC50: 0.074 nM),具有有效性、选择性和非竞争性,可用于研究性成熟。
¥352.00
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Bifemelane hydrochloride
目录号:SY-127605
Bifemelane hydrochloride 是一种选择性的,有效的,和竞争性的单胺氧化酶A (MAO-A)抑制剂,Ki=4.20 μM,它也非竞争性地抑制MAO-B,Ki=46.0 μM。它具有显著的抗抑郁作用,可用于研究与脑血管疾病有关的认知和情绪障碍。
¥8568.00
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DSG-PEG (MW 2000)
目录号:SY-127470
DSG-PEG (MW 2000) 是一种聚乙二醇修饰的脂质(PEG-lipid),主要用作制备脂质纳米颗粒(LNP)和脂质体的关键药用辅料。其结构中包含二硬脂酰甘油锚点,能在脂质双分子层中提供较强的锚定作用。在核酸递送系统中,DSG-PEG (MW 2000) 的比例和链长直接影响纳米颗粒的粒径、循环稳定性以及与细胞相互作用的动力学,是优化 mRNA 递送效率和组织靶向性的重要工具。
¥1851.00
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Linezolid
目录号:SY-127599
Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素,抑制细菌蛋白质合成的起始阶段,具有抗感染作用。
¥1713.00
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PF-04449613
目录号:SY-128132
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-04449613 (10 mg/kg) increases the rate of dendritic spine formation and elimination in mouse primary motor cortex pyramidal neuronsin vivo.2It increases the average running speed of mice in an accelerating rotarod task, indicating improved motor learning, at the same dose. 1.Claffey, M.M., Helal, C.J., Verhoest, P.R., et al.Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitorsJ. Med. Chem.55(21)9055-90
¥1955.00
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Dioleyldimethylammonium chloride
目录号:SY-127467
Dioleyldimethylammonium chloride(DODAC)作为一种阳离子脂质,广泛应用于转染试剂领域。
¥368.00
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9322-O16B
目录号:SY-127468
9322-O16B为一种可电离的阳离子脂质,适用于LNP的生成。
¥621.00
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Coumarin102
目录号:SY-127633
Coumarin102 (Exciton 480)是一种荧光染料。Coumarin102对Monoamine oxidase B、MAO-B和MAO-A具有较弱的抑制活性,可用来研究神经系统疾病。
¥6428.00
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