Arylsulfonamide 64B

目录号：SY-127017

Arylsulfonamide 64B (HIF inhibitor 64B) 作为一种有效的缺氧诱导因子 (hypoxia induced factor, HIF) 抑制剂，通过抑制缺氧/HIF 诱导的 c-Met 和 CXCR4 的表达，能显著降低葡萄膜黑色素瘤小鼠模型中原发肿瘤的生长与转移。

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PHD-IN-2

目录号：SY-127018

PHD-IN-2（Compound 91）是一种高效的PHD拮抗剂，具有IC50值小于5 nM，能在HEP3B细胞中诱导促红细胞生成素的合成，EC50值小于2.5 μM。此化合物主要用于心血管、代谢、血液、肺部、肾脏、肝脏疾病、伤口愈合以及癌症等研究领域。

¥1702.00

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(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

目录号：SY-127019

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 是一种能同时靶向Smad3的泛素化和降解并提高HIF-α蛋白水平的双靶点PROTAC，展现出对肾性贫血的多途径抗纤维化和肾脏保护作用。

¥3415.00

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Moracin O

目录号：SY-127020

Moracin O是一种发现于Morus alba Linn.的天然产物，对3T3-L1，RAW 264.7和HEP 3B具有细胞毒性，对HIF-1具有抑制作用，具有神经保护和抗炎作用。

¥4772.00

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HIF-1 alpha (556-574)

目录号：SY-127021

HIF-1 alpha (556-574) is a 19-mer fragment of hypoxia-inducible factor-1, a master regulator of the response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when the HIF-1 subunit is stabilized in response to a lack of oxygen.

¥3726.00

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ZG-2033

目录号：SY-127022

ZG-2033 (Compound 26) 是口服活性HIF-2α激动剂，在荧光素酶报告基因测定中具有纳摩尔活性 (EC50= 490 nM)。ZG-2033 能减轻贫血，并与 AKB-6548 在贫血治疗中表现出协同作用，可用于肾性贫血研究。

¥103.00

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HIF-1α-IN-3

目录号：SY-127023

HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].

¥285.00

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HIF-PHD-IN-1

目录号：SY-127024

HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.

¥784.00

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GSK360A

目录号：SY-127025

GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.

¥115.00

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