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GSK3β-IN-3
目录号:SY-123719
GSK3β-IN-3 是一种 ATP 竞争性GSK-3β抑制剂 (IC50= 0.90 μM),具有优异的血脑屏障通透性 (Pe= 10.7 x 10-6 cm/s)。GSK3β-IN-3 能降低 BR5706 菌株中 tau 蛋白的磷酸化水平,并减少 CL2006 菌株中的 Aβ 聚集体沉积,显示出作为阿尔茨海默病 (AD) 研究候选物的潜力。
¥201.00
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Moricizine Hydrochloride
目录号:SY-123720
Moricizine Hydrochloride (EN 313) 是一种口服具有活力的 I 类抗心律失常剂。Moricizine Hydrochloride 能够减少 0 相去极化的速率;提高 2 相和 3 相复极率,降低动作电位持续时间,减少有效不应期。
¥402.00
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(±)17-HETE
目录号:SY-123721
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.
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1β-Hydroxydeoxycholic acid
目录号:SY-123722
1β-Hydroxydeoxycholic acid (1β-OH-DCA)为次级胆汁酸,同时作为CYP3A的生物标志物。在使用重组人CYP450酶的过程中,Deoxycholic acid 通过CYP3A4和CYP3A7的特异性代谢转化为1β-Hydroxydeoxycholic acid。
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Testololactone
目录号:SY-123723
Testololactone,一种芳香酶抑制剂,常用于乳腺癌研究。
¥5750.00
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Dihydrocubebin
目录号:SY-123724
Dihydrocubebin,一种从Piper cubeba中分离的化合物,表现出对细胞色素P450 3A4 (CYP3A4) 的有效且选择性抑制。
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(R)-6',7'-Dihydroxybergamottin
目录号:SY-123725
(R)-6',7'-Dihydroxybergamottin is an ihhibitor of CYP1A1 and the isomer of 6',7'-Dihydroxybergamottin(DHB).
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Isavuconazole-D4
目录号:SY-123726
Isavuconazole-D4 Isavuconazole (T2305)D4 is a deuterium labeled Isavuconazole. Isavuconazole (T2305) is a triazole prodrug with antifungal activity against yeasts,molds,and dimorphic fungi.
¥2369.00
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Tebuconazole-D9
目录号:SY-123727
Tebuconazole-D9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole (T17022) is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM,respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM)and is cytotoxic (EC20 = 38.9 µM)in an MDA-kb2 assay. Tebuconazole (T17022) (50 and 100 mg/kg per day)administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42,tebuconazole (20 and 60 mg/kg per day)leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learni
¥3703.00
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