Dasatinib Analog-1，其Ki值为5.4 μM，能够抑制CYP3A4活力，并能阻断谷胱甘肽加合物的形成。

EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes.

(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).

17(S)-HETE是一种通过CYP450途径产生的花生四烯酸代谢物。17(S)-HETE是一种CYP450 1B1的变构激活剂和ATPase抑制剂，能够诱导心脏肥大。

MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

WAY-325412 是一种用于调控 CYP450 活性的化合物，常用于评估负鼠和小鼠肝微粒体中 CYP3A 的催化活性。其应用支持跨物种代谢研究、药物–酶相互作用分析以及比较肝生物学研究，有助于深入理解外源化合物的生物转化通路。

Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]

(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.

Quinidine sulfate 是一种抗心律失常剂，是有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM。Quinidine sulfate 也可用于疟疾的研究。