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6',7'-Epoxybergamottin
目录号:SY-123746
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.
¥920.00
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(±)-ε-Viniferin
目录号:SY-123747
(±)-ε-Viniferin,ε-Viniferin的外消旋体,展现P450抑制性抗氧化、保肝及抗菌特性。该化合物对革兰氏阳性菌肺炎链球菌显示出抗菌和抗生物膜活性,最小抑制浓度(MIC)为20 μM。
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Secologanin
目录号:SY-123748
Secologanin is a monoterpene that has been found in V. rosea and is an intermediate in the synthesis of monoterpene indole alkaloids from geraniol.
¥828.00
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Aschantin
目录号:SY-123749
Aschantin 是一种从植物中分离到的木脂素类天然产物。
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(+)-Menthofuran
目录号:SY-123750
(+)-Menthofuran 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125544。
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Indole-2-carboxaldehyde
目录号:SY-123751
Indole-2-carboxaldehyde是吲哚类杂环的经典合成中间体,可用于吲哚类生物碱、医药分子、农药、荧光探针等化合物合成。Indole-2-carboxaldehyde对hCYP2A6具有抑制作用,IC50的值为1.8 μM。
¥29.00
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2-Hydroxy-1-Methoxyaporphine
目录号:SY-123752
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
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CYP19A1/CYP11B2-IN-1
目录号:SY-123753
CYP19A1/CYP11B2-IN-1 是一种高效的芳香化酶(CYP19A1)和醛固酮合酶(CYP11B2)双重抑制剂,其 IC₅₀分别为 2.3 nM 和 29 nM。CYP19A1/CYP11B2-IN-1 可以抑制乳腺癌细胞增殖并促凋亡(对 MCF-7 细胞的 IC₅₀为 0.26 ± 0.03 μM)。CYP19A1/CYP11B2-IN-1 可以通过抑制 mTOR 磷酸化来负调控 PI3K/Akt/mTOR 信号通路。
¥2530.00
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1-Trityl-1H-imidazole
目录号:SY-123754
1-Trityl-1H-imidazole 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66710,CAS号为 15469-97-3。
¥34.00
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