The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.

ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.

GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The compound demonstrates anti-inflammatory properties and hinders the recruitment of immune cells in the intestinal muscularis of mice.

PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).

ERK1/2 inhibitor 7 是一种 ERK 的有效抑制剂，作用于 ERK2 (IC50: 0.94 nM)。

Alpinumisoflavone 是一种从 Laburnum alpinum 中提取的天然异戊烯基异黄酮。Alpinumisoflavone 通过抑制 NF-κB、MAPK 和 NLRP3 炎症小体通路，发挥抗炎和抗氧化作用。Alpinumisoflavone 还具有抗肿瘤活性。

p-Cresyl Sulfate 是主要的尿毒症毒素，存在于慢性肾病患者的血液，来源于肝脏中酪氨酸和苯丙氨酸的代谢物。

JNK-IN-8 (JNK Inhibitor XVI) 是一种有效的 JNK 抑制剂，抑制 JNK1、JNK2 和 JNK3，IC50 分别为 4.7、18.7 和 1 nM。JNK-IN-8 具有脱靶极低、抑制持久、特异性极强的优点。JNK-IN-8 主要通过阻断 JNK/c-Jun 信号通路，抑制下游转录因子 c-Jun 的磷酸化，从而调控与炎症反应、细胞凋亡及应激反应相关的基因表达。JNK-IN-8 可用于肿瘤 、 炎症 、神经疾病研究。

Ginsenoside Re (Ginsenoside B2) 是一种人参提取物，可降低 β-淀粉样蛋白 (Aβ)，还通过抑制 JNK 和 NF-κB 发挥抗炎作用。