Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.

Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) and serves as a natural substrate for Akt/PKB.

TAT-TCL1-Akt-in 是一款有效的Akt抑制剂。

substrate for Akt/PKB

IPL344 保护各种类型的细胞免受促凋亡压力影响，并激活Akt信号传导。IPL344 可用于 [肌萎缩侧索硬化症 (ALS)] 的研究。

Scalaradial 是一种抑制剂，针对蜂毒磷脂酶 A2 (PLA2) 和TRPM离子通道 (TRPM2) 的IC50分别为 0.07 和 0.21 μM。它通过抑制分泌性PLA2和Akt，调节ERK的磷酸化。Scalaradial 还可以抑制PMA诱导的小鼠腹膜巨噬细胞中Arachidonic acid的释放。

Itacnosertib hydrocholide为JAK2、ACVR1 (ALK2) 及ALK5的抑制剂。

LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

INY-05-040 是 AKT 降解剂，能够快速且选择性地降解所有三种 AKT 异构体，并抑制 288 个癌细胞系中的下游信号和细胞增殖，展现出抗癌活性。