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Communic acid
目录号:SY-109292
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
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Procyanidin A1
目录号:SY-109972
Procyanidin A1 (Proanthocyanidin A1) 是一种原花青素二聚体,具有抗过敏作用,可抑制蛋白激酶 C 激活下游脱粒或 RBL-213 细胞内部储存的 Ca2+流入。
¥898.00
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Asciminib hydrochloride
目录号:SY-109439
Asciminib hydrochloride 被归类为“STAMP inhibitor”,特异性靶向 ABL 的 myristoyl pocket。Asciminib hydrochloride(商品名 Scemblix)通过与野生型 ABL N 端的别构位点结合发挥作用,而该结构域在 ABL 融合蛋白中缺失,使其能够选择性调控与 Philadelphia 染色体阳性慢性髓性白血病(Ph+ CML)相关的致癌信号通路,是血液肿瘤研究中的重要靶向工具化合物。
¥460.00
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Vatelizumab
目录号:SY-109742
Vatelizumab是一种靶向Integrin α2β1(very late antigen 2,VLA-2,CD49b)的人源化单克隆抗体,能够通过p38 MAPK信号来增强调节性T细胞的频率,可用于研究多发性硬化症。
¥4347.00
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Zelavespib HCl
目录号:SY-109562
Zelavespib HCl是一种新型Hsp90抑制剂,是一种新型嘌呤基类似物,也是一种可能是CIRT的一种有前途的放射增敏剂。Zelavespib HCl 在许多恶性肿瘤临床前模型中显示出抗肿瘤活性。Zelavespib HCl对 Rad51 和Ku70 的蛋白表达水平有抑制作用,这可能与双链断裂修复的同源重组途径和非同源末端连接途径有关。
¥230.00
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Nyasol
目录号:SY-109301
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly
¥5985.00
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para-Nitroblebbistatin
目录号:SY-109937
para-Nitroblebbistatin 是无细胞毒性、无荧光、光稳定、特异性的肌球蛋白 II (Myosin II) 抑制剂。para-Nitroblebbistatin 可用于肌球蛋白 II 在生理学、发育和细胞生物学中特殊作用的相关研究。
¥1386.00
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Ellipticine quinone
目录号:SY-109467
Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-​1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)​. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury.
¥1155.00
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E7820
目录号:SY-109686
E7820 (ER68203-00) 是具有口服活性芳香族磺酰胺衍生物,是一种血管生成抑制剂,可抑制内皮上整合素 α2 亚基的表达。它调节 α1,α2,α3 和 α5 整联素 mRNA 表达,具有抗血管生成和抗肿瘤活性。它抑制大鼠主动脉血管生成,IC50为 0.11 μg/ml。
¥380.00
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