Gambogic amide acts as a potent and selective agonist for TrkA, promoting tyrosine phosphorylation and activating downstream signaling pathways such as Akt and MAPK. It specifically binds to the cytoplasmic juxtamembrane domain of the TrkA receptor, stimulating dimerization and activation. The compound demonstrates neuroprotective properties by preventing neuronal cell death caused by glutamate. Additionally, gambogic amide shows enhanced efficacy in a transient middle cerebral artery occlusion model of stroke and may be useful for investigating neurodegenerative diseases and stroke [1].

7,4'-Dimethoxy-3-hydroxyflavone 是一种有效的口服PAR4拮抗剂，其IC50为1.4 μM，能够抑制PAR4介导的人血小板聚集，同时抑制相关信号通路，如NF-κB、Ca2+/蛋白激酶C (PKC)、Akt、ERK和p38。在链脲佐菌素 (STZ) 诱导的糖尿病小鼠模型中，该化合物能减少血管PAR4的表达，改善内皮功能障碍并缓解氧化应激。此外，7,4'-Dimethoxy-3-hydroxyflavone 能在不延长出血时间的情况下防止小鼠血栓形成。

Adonixanthin ((3S,3'R)-Adonixanthin) 是一种类胡萝卜素，具备口服活性的抗氧化和抗癌特性。它能有效抑制三种胶质母细胞瘤细胞的增殖与迁移，并通过多种途径提供细胞保护作用，尤其是在抑制活性氧 (ROS) 产生方面表现出色。Adonixanthin 不仅通过抗氧化反应保护细胞，还通过激活Nrf2减少光诱导的损伤。它能够减缓胶质母细胞瘤的进展，并在自体血脑出血 (ICH) 模型中改善血脑屏障的通透性升高。Adonixanthin 适用于胶质母细胞瘤 (GBM) 和脑出血 (ICH) 研究。

6-O-Caffeoylarbutin(Robustaside B)是一种抗氧化的天然产物，能够诱导线粒体膜通透性转变，能够调节SIRT1/PI3K/AKT/NF-κB通路，改善小鼠的肝损伤和缺血性脑卒中症状。

Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.

Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c

Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) .

Pre-084 是一种高亲和力、选择性的 σ1 激动剂。

SB 699551是一种选择性的5-HT5A拮抗剂（Ki=6.31 nM），能够增强5-HT神经元功能。SB 699551能够抑制SERT（Ki=25.12 nM），降低AKT和FOXO1的磷酸化水平，对乳腺癌具有抑制作用。